Saxenda (Liraglutide) for Weight Loss: The Good and The Bad – Updated 2025

What is Saxenda (Liraglutide)?

Saxenda is a medication used to help people with obesity or overweight-related health conditions lose weight. It contains the active ingredient liraglutide, which works by mimicking a hormone called GLP-1 in the body. This hormone helps to regulate hunger, making you feel fuller, eat less, and ultimately lose weight. Saxenda is often prescribed alongside a reduced-calorie diet and increased physical activity.

The Good: What Makes Saxenda Effective?
  1. Proven Weight Loss Benefits: Saxenda has been shown to help people lose weight when used alongside lifestyle changes like diet and exercise. Studies have found that people using Saxenda lose more weight than those who don’t use the medication. On average, people can lose between 5-10% of their body weight when using Saxenda for several months.
  2. Helps Control Appetite: Saxenda helps reduce hunger, making it easier for you to stick to a calorie-controlled diet. By increasing feelings of fullness, Saxenda can make it less tempting to overeat or snack between meals.
  3. FDA-Approved for Chronic Weight Management: Saxenda is approved by the U.S. Food and Drug Administration (FDA) for long-term use in people with obesity or overweight conditions such as type 2 diabetes, high blood pressure, or heart disease. It can help improve overall health by managing weight.
  4. Suitable for Different Populations: Saxenda can be used in both adults and children over the age of 12 who are struggling with obesity. It’s an option for individuals who have not been able to lose weight through diet and exercise alone.
  5. Improves Other Health Markers: As you lose weight with Saxenda, you may see improvements in your overall health, such as lower blood sugar levels, reduced blood pressure, and improved cholesterol levels. This is particularly beneficial for individuals with obesity-related health conditions like type 2 diabetes.
The Bad: Potential Side Effects and Risks
  1. Gastrointestinal Side Effects: Many people experience some form of stomach discomfort when using Saxenda. The most common side effects include:
    • Nausea
    • Vomiting
    • Diarrhea
    • Constipation
    • Abdominal pain
    • These side effects can be quite bothersome, especially during the first few weeks of treatment. Some people may find it difficult to continue the medication because of these symptoms.

  2. Serious Health Risks: Though rare, there are some serious risks associated with Saxenda:
    • Thyroid Cancer Risk: Studies in animals have shown that Saxenda could increase the risk of thyroid cancer. Although this risk hasn’t been proven in humans, the FDA has issued a warning about it.
    • Pancreatitis: Some people have developed inflammation of the pancreas (pancreatitis) while using GLP-1 drugs like Saxenda. This can cause severe abdominal pain, nausea, and vomiting.
    • Kidney Problems: Saxenda has been linked to kidney issues, especially in people who have pre-existing kidney disease or dehydration.
    • Mental Health Concerns: In rare cases, some users have experienced mood changes, including feelings of depression and thoughts of suicide. If you notice any mental health changes while on Saxenda, seek medical advice immediately
  3. Weight May Return After Stopping Saxenda: Once you stop using Saxenda, the weight you lost may be regained if you don’t continue to follow a healthy diet and exercise routine. This is why Saxenda is generally recommended as a long-term treatment, not a quick fix.
  4. Cost and Access: Saxenda can be expensive, and in some cases, insurance may not cover the cost. The cost can be a barrier for some people who need the medication for long-term weight management.
  5. Discontinuation Due to Side Effects:Studies have shown that a significant number of people stop using Saxenda because of side effects. If gastrointestinal problems become severe or difficult to manage, you may need to consider alternative treatments.
Important Considerations Before Starting Saxenda
  1. Consult Your Healthcare Provider It’s essential to speak with your doctor before starting Saxenda. Your doctor will assess your health status, including any other medications you’re taking, to ensure that Saxenda is a safe option for you. People with certain medical conditions, such as a history of thyroid cancer, pancreatitis, or kidney problems, may not be advised to use Saxenda.
  2. Start Slowly to Minimize Side Effects To reduce the chances of side effects, Saxenda is typically started at a low dose, which is gradually increased over several weeks. This helps your body adjust to the medication and minimizes nausea and other digestive problems.
  3. Lifestyle Changes Are Key Saxenda is most effective when combined with lifestyle changes such as eating a balanced, calorie-controlled diet and engaging in regular physical activity. It’s not a substitute for a healthy lifestyle, but rather a tool that can support your weight loss efforts.
  4. Stay Monitored Regular check-ins with your healthcare provider are important while using Saxenda. Your doctor will want to monitor your progress, adjust your dosage if needed, and watch for any potential side effects.
Alternatives to Saxenda

If Saxenda isn’t right for you or you experience too many side effects, there are other medications and treatments available for weight loss. For instance:

  1. Semaglutide (Wegovy): Another GLP-1 medication, Wegovy, has shown even greater results in weight loss compared to Saxenda. It may be a suitable alternative.
  2. Orlistat (Alli): This medication works by blocking some of the fat you eat from being absorbed in your intestines. It's available over the counter.
  3. Bariatric Surgery: For people with severe obesity, surgical options like gastric bypass or sleeve gastrectomy may be considered.
Final Thoughts

Saxenda (liraglutide) can be an effective tool for weight loss, especially for people with obesity or weight-related health issues. However, it’s important to be aware of both the benefits and risks. If you’re considering Saxenda, talk to your doctor to make sure it’s the right choice for you. And remember, the best results come from combining the medication with healthy lifestyle habits, such as diet and exercise.



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